Content Library Longevity Journal

Igobaine for the Brain: From Addiction to Performance

February 10, 2025

Just a few weeks ago, a fascinating new study from Stanford reported that a plant-based psychoactive drug called ibogaine could be a breakthrough for brain health.¹ 

The researchers found that ibogaine reduced symptoms of PTSD, anxiety, and depression, and significantly improved cognitive performance in veterans who’ve experienced traumatic brain injuries.

In fact, the scientists wrote: “No other drug has ever been able to alleviate the functional and neuropsychiatric symptoms of traumatic brain injury,” and “the results are dramatic…”

While these findings are compelling, ibogaine is still a relatively new area of research. But if it can help repair brain function after serious injury, what could that mean for other conditions—like chronic stress, cognitive decline, or even everyday mental performance?

Some scientists are hopeful about its potential—not just for brain repair, but also for treating addiction.

So what, exactly, is ibogaine? And how does it work?

I’ll break down the science and share what this could mean for your brain health.

What Is Ibogaine?

Ibogaine is a natural compound found in the root bark of Tabernanthe iboga, a small shrub native to West Central Africa. 

Traditionally, it’s been used in spiritual ceremonies, but in recent years, it’s gained attention for its potential to influence brain health in profound ways.

Most notably, ibogaine has been studied for its ability to help people overcome addiction, particularly to opioids. Some research suggests that it works on the brain in ways that may reset addictive behaviors and reduce withdrawal symptoms.

But addiction isn’t the only area where ibogaine is showing promise. Researchers are now investigating whether it could help with depression, psychological trauma, and even brain injuries. 

That’s what led to the recent study from Stanford, which looked at its effects on veterans with traumatic brain injuries.

What Did the Research Show? 

The Stanford-backed study tested whether a treatment combining ibogaine and magnesium could help veterans with traumatic brain injuries (TBI).

The study included 30 male Special Operations Forces veterans who had suffered mild TBIs, often from repeated blast or combat exposures. Participants traveled to Mexico, where they received the MISTIC protocol—ibogaine combined with magnesium.

Researchers measured the participants’ disability levels, PTSD, depression, and anxiety symptoms before treatment and again one month later.

The Results

The findings were striking:

• Improved daily function: Disability levels dropped from mild-to-moderate to no-to-mild.
  
  
• Major reductions in PTSD, depression, and anxiety: PTSD severity decreased by 81 percent, with anxiety and depression symptoms improving by more than 80 percent.
  
  
• Enhanced cognitive performance: Processing speed and executive function improved without declines in other areas.
  
  
• Generally well tolerated: Some participants reported mild side effects like nausea and headaches, but no serious adverse events occurred.

While promising, the study had limitations:

• Small sample size: With only 30 male participants from elite military units, results may not apply to a broader population.
  
  
• No control group: Without a placebo, it’s unclear whether improvements were due to ibogaine or other factors.

Though early findings suggest ibogaine may have therapeutic potential, larger, controlled trials are needed to determine its true effectiveness and safety.

So, How Does Ibogaine Work?

While researchers are still uncovering the exact ways ibogaine works, they believe it operates by interacting with multiple systems in the brain. 

It influences key neurotransmitters—chemical messengers that help brain cells communicate. ² For example, ibogaine affects serotonin (which influences mood), dopamine (critical for motivation and reward), and glutamate (important for learning and memory).

Does Ibogaine Have Any Side Effects?

Ibogaine’s potential comes with some risks. It has been associated with serious issues, including heart complications like QT prolongation, which can lead to dangerous arrhythmias (irregular heartbeats). ³ These risks are why ibogaine must be administered in a controlled setting with careful medical monitoring.

The Stanford study offers an encouraging finding: Pairing ibogaine with magnesium seemed to reduce these risks. Magnesium may help counteract QT prolongation, providing an extra layer of safety during treatment.

Should You Consider Ibogaine?

Ibogaine isn’t currently approved by the FDA for any medical use in the United States, which means it’s not available through conventional healthcare providers. 

However, international clinics in countries where ibogaine is legal—such as Mexico—do offer treatments. In fact, the Stanford study was conducted in such a setting, highlighting how important medical oversight is when using ibogaine. That said, it’s crucial to weigh the risks carefully and only administer under the guidance of a qualified physician.

How to Optimize Your Own Brain Health 

While ibogaine’s potential is exciting, it could be years before it’s widely available. Fortunately, there are steps you can take right now to support cognitive performance and overall brain health.

The basics—exercise, proper nutrition, and quality sleep—remain the foundation for keeping your brain sharp and resilient. 

But if you’re looking for an extra boost, research suggests that certain supplements may help:

• Omega-3 fatty acids (DHA and EPA): Found in fish oil, these healthy fats support brain structure and function while reducing inflammation that can impair cognition.
  
  
• Creatine: Known for enhancing physical performance, creatine also supports brain energy metabolism, potentially improving memory and mental clarity.
  
  
• Lion’s mane mushroom: A popular nootropic, lion’s mane may promote the growth of new brain cells and improve memory and focus.
  
  
• Vitamin D: This essential nutrient supports overall brain health and mood regulation, but many people are deficient—making supplementation a smart move.

Of course, for a more comprehensive approach to optimizing brain health and overall well-being, working with a Functional Medicine practitioner can provide deeper insights. 

At the UltraWellness Center, we take a whole-body approach to help you fine-tune nutrition, lifestyle, and personalized strategies for long-term health. Schedule an appointment to learn more about how we can support your health goals.

References

1. Cherian, K.N., Keynan, J.N., Anker, L. et al. Magnesium–ibogaine therapy in veterans with traumatic brain injuries. Nat Med 30, 373–381 (2024). 

2. Köck P, Froelich K, Walter M, Lang U, Dürsteler KM. A systematic literature review of clinical trials and therapeutic applications of ibogaine. J Subst Abuse Treat. 2022 Jul;138:108717. 

3. Litjens RP, Brunt TM. How toxic is ibogaine? Clin Toxicol (Phila). 2016;54(4):297-302.