Overview
Medicine stands at the threshold of a new era, where artificial intelligence and systems biology are working hand in hand to make care more personal, predictive, and precise than ever before. AI is already improving diagnostic accuracy, automating administrative tasks, and uncovering patterns in data—like retinal scans or genomics—that humans often miss. Rather than replacing doctors, AI enhances their ability to deliver more informed, precise, and efficient care. At the same time, individuals are gaining tools—from at-home diagnostics to wearable biosensors—that empower them to track and optimize their own health. This shift marks a move from reactive, disease-centered care to a proactive, data-driven model of scientific wellness.
In this episode, I talk with Dr. Eric Topol, Dr. Nathan Price, Dr. Leroy Hood, Dr. Vijay Pande, and Daisy Wolf about how artificial intelligence, personalized data, and wearable technology are converging to radically transform medicine.
Dr. Eric Topol is the Executive Vice-President of Scripps Research, the largest non-profit biomedical research in the United States, where he was the founder and directs the Scripps Research Translational Institute as Chairman and Professor of Translational Medicine. He has published over 1,300 peer-reviewed articles, with more than 370,000 citations, elected to the National Academy of Medicine, and is one of the top 10 most cited researchers in medicine. He authored three bestseller books on the future of medicine: The Creative Destruction of Medicine, The Patient Will See You Now and Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. His latest book is Super Agers: An Evidence-Based Approach to Longevity. Topol is the principal investigator of two large NIH grants, the All of Us ResearchProgram that supports precision medicine and a Clinical and Translational Science (CTSA) Award that promotes innovation in medicine. He was the founder of a new medical school at ClevelandClinic (Lerner College of Medicine), was commissioned by the UK to lead a review of their NationalHealth Service, and is active clinically as a cardiologist. At Substack, he publishes Ground Truths, a weekly newsletter and podcast on cutting edge biomedical advances.
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. In 2019, he was named one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine. He is Affiliate Faculty at the University of Washington in Bioengineering and Computer Science and Engineering.
Dr. Leroy Hood is the CEO and founder of Phenome Health, a non-profit organization developing a project called Human Phenome Initiative (HPI), based on the science of wellness, which will sequence the genes and generate the longitudinal phenomes of one million people over 10 years. He has co-founded 17 biotech companies. His many national and international awards include the Lasker Prize, the Kyoto Prize, and the National Medal of Science. He is also the Chief Strategy Officer/Professor at the Institute of Systems Biology in Seattle.
Vijay Pande, PhD, is a General Partner and has been at Andreessen Horowitz since 2014. He founded and leads a16z Bio + Health, which invests in life sciences and healthcare through four dedicated funds with more than $3 billion under management. Vijay leads the firm’s investments at the cross section of biology and computer science, including applications in computation, machine learning, and artificial intelligence in healthcare; digital therapeutics; diagnostics; and other novel transformative scientific advances applied to industry that take bio beyond healthcare. He is also an Adjunct Professor of Structural Biology at Stanford University. He holds a BA in Physics from Princeton University and a PhD in Physics from MIT. He has been awarded the DeLano Prize in Computation, a Guinness World Record for Folding@Home, the American Chemical Society Thomas Kuhn Paradigm Shift Award, and was selected for MIT TR10. In his teens, Vijay was the first employee at video game startup Naughty Dog, maker of Crash Bandicoot and The Last of Us.
Daisy Wolf is an investing partner at Andreessen Horowitz, where she focuses on healthcare technology. In particular, she specializes in healthcare AI and software, consumer health, and the intersection of healthcare and fintech. Prior to joining Andreessen Horowitz, Daisy worked at Meta in the Global Business Group, where she led company growth efforts within government and politics. In addition, Daisy has held various roles at multiple startups and covered technology at a hedge fund. Daisy holds a JD from Yale Law School, an MBA from the Stanford Graduate School of Business, and a BA, Phi Beta Kappa from Yale College. Daisy is based in New York City.
Full-length episodes can be found here:
Can AI Fix Our Health and Our Healthcare System?
The Next Revolution In Medicine: Scientific Wellness, AI And Disease Reversal